Most non-ossifying fibromas are found in the metaphysis of long bones of the lower extremities such as the distal femur and the distal lateral and proximal medial tibia 1,2,6. They might occur in the background of germline mutations resulting in the RAS-MAPK pathway 5 or postzygotic mutations in neurofibromatosis type 1 or Jaffe-Campanacci syndrome 1. The etiology of sporadic non-ossifying fibromas is not known 1. Indeed, it is believed that many bone islands are healed non-ossifying fibromas ref. The irony of non-ossifying fibromas appearing to ossify has not been lost on generations of radiologists, although strictly speaking the lesion itself does not ossify, rather being filled in by normal bone from the periphery 4. They are biologically active and can grow initially become more polycyclic and regress after puberty filling up gradually with bone from the diaphyseal side 3. Non-ossifying fibromas are benign spindle cell tumors of bone containing osteoclast-like giant cells 1-3. Non-ossifying fibromas might cause a pathological fracture if large. Larger tumors can have an impact on the biomechanical properties of the affected bone and cause pain 1. Non-ossifying fibromas are usually asymptomatic 1,2 and incidentally found in imaging studies 3. interspersed giant cells, haemosiderophages and clusters of foamy histiocytes.storiform proliferation of plump spindle cells.metaphyseal location in long bones in skeletally immature individuals.The following additional criteria are desirable: bone tumor with typical imaging findings.Diagnostic criteriaĭiagnostic criteria according to the WHO classification of soft tissue and bone tumors (5 th edition) 1: They are considered as ‘do not touch’ or ‘leave me alone lesions’ 4. The diagnosis of non-ossifying fibromas is mainly based on characteristic radiographic or imaging features 1. Non-ossifying fibromas have been found in association with the following 1,3: They are usually not seen beyond the age of 30 as they heal spontaneously after puberty and ossify gradually 2-5. They are about twice as common in boys than in girls 1,3. Their frequency has been estimated at around 30-40% of all normal children with a peak in the second decade 1-4.
The true incidence of non-ossifying fibromas is not known because most lesions are not detected due to the absence of clinical symptoms and the benign natural history of the lesions 1. Non-ossifying fibromas are very common in children and adolescents and are considered the most common benign tumor 1-5. These synonyms for the word heal are provided for your information only.The terms ‘fibrous cortical defect’ (confined to the cortex), ‘metaphyseal fibrous defect’ or ‘benign fibrous histiocytoma' are no longer recommended 1. is more than 70,800 synonyms and 47,200 antonyms available. This site allows you to find in one place, all the synonyms and antonyms of the English language. In your daily life, for writing an email, a text, an essay, if you want to avoid repetitions or find the opposite meaning of a word. The words blockage, encumbrance, handicap are antonyms for "help". The words acknowledge, enjoy, welcome are synonyms for "appreciate". Antonyms are used to express the opposite of a word. Antonym definitionĪn antonym is a word, adjective, verb or expression whose meaning is opposite to that of a word. This avoids repetitions in a sentence without changing its meaning. Synonyms are other words that mean the same thing. Extract from : « Mistress Wilding » by Rafael SabatiniĪ synonym is a word, adjective, verb or expression that has the same meaning as another, or almost the same meaning.You compel me to hurt you I do so as the surgeon does-that I may heal you.Extract from : « Captain Blood » by Rafael Sabatini.I'm thinking it's more pleasing in the sight of Heaven to kill men than to heal them.Apollo was also bidden to heal their wounds and compose their forms.Extract from : « Memoirs of the Court of St.The wound inflicted may heal, but the scar will always remain.Can you heal my mother's broken heart,-broken, long ago by my disgrace?.It would be ridiculous for me to try to heal you with big phrases.The desire to be healed did heal the thirst for a miracle worked the miracle.Extract from : « The Three Cities Trilogy, Complete » by Emile Zola.To be all-powerful and heal every one of them, was not that the desire which rose from each heart?.Extract from : « Miracles of Our Lord » by George MacDonald.I suspect it was but another shape of the virtue that went forth to heal.Extract from : « United States Presidents' Inaugural Speeches » by Various.So we voice our hope and our belief that we can help to heal this divided world.
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